![]() Two clinical conditions are now linked to BP use: atypical femoral fractures where the femur breaks without warning, 11 and osteonecrosis of the jaw, which causes poor bone healing following dental work. 9 This increase in BMD is thought to be the result of microarchitectural changes caused by BP, 10 but the mechanical consequences of these changes may not be entirely benign. 6, 7 BP is said to improve bone strength by reducing bone remodelling 8 and increasing DXA-based measures of bone mineral density (BMD). 3, 5 The bisphosphonate (BP) family of drugs has, for some years, been the first-line treatment option for prevention of fragility fractures. These imaging modalities quantify the amount of bone mineral present per unit area or volume and correlate reasonably with fracture risk. 1, 2 This process is characterised by a reduction in bone mass, resulting from a reduction in the number, thickness, and connectivity of trabeculae, which can be documented and monitored by dual energy X-ray absorptiometry (DXA) 3 or quantitative computed tomography (QCT) 4 imaging. Carson City Nevada, USA.Bone fragility, or osteoporosis, is a major disease affecting 200 million people worldwide and contributing to 8.9 million fractures annually. This page, and all contents, are Copyright © 1984-2022 WHE Inc.
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